A needle of a small-gauge catheter can be inserted into tissue at various sites including the thighs, abdominal wall, back, thorax and arms.  Only isotonic or hypotonic solutions are appropriate for this infusion method.   Fluids are efficiently absorbed into the vasculature.  The infusion volume at a single site should be limited to approximately 1.5 L during a 24-hour period.  The infusion rate should be maintained above 20 mL per hour to prevent clogging of the line and below 75 mL per hour to prevent localized swelling.

Subcutaneous fluid therapy is not appropriate in the management of severe dehydration.  The amount the rate of absorption for rehydration is limited.  Lastly, catheters should be replaced every 48 - 72 hours or sooner if signs of infection develop.